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        5. Discovery of the Psychic Effects of LSD

          The solution of the ergotoxin problem had led to fruit­ful results, described here only briefly, and had opened up further avenues of research.

          And yet I could not forget the relatively uninteresting LSD-25. A peculiar presentiment—the feeling that this substance could possess properties other than those established in the first investigations—induced me, five years after the first synthesis, to produce LSD-25 once again so that a sample could be given to the pharmacological de­partment for further tests.

          This was quite unusual; experimental substances, as a rule, were definitely stricken from the research program if once found to be lacking in pharmacological interest.

          Nevertheless, in the spring of 1943, I repeated the synthesis of LSD-25.

          As in the first synthesis, this involved the production of only a few centigrams of the compound.

           

          In the final step of the synthesis, during the purifica­