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Discovery of the Psychic Effects of LSD
The solution of the ergotoxin problem had led to fruitful results, described here only briefly, and had opened up further avenues of research.
And yet I could not forget the relatively uninteresting LSD-25. A peculiar presentiment—the feeling that this substance could possess properties other than those established in the first investigations—induced me, five years after the first synthesis, to produce LSD-25 once again so that a sample could be given to the pharmacological department for further tests.
This was quite unusual; experimental substances, as a rule, were definitely stricken from the research program if once found to be lacking in pharmacological interest.
Nevertheless, in the spring of 1943, I repeated the synthesis of LSD-25.
As in the first synthesis, this involved the production of only a few centigrams of the compound.
In the final step of the synthesis, during the purifica­